RAF Proto-Oncogene Serine/Threonine-Protein Kinase

Preferred Label : RAF Proto-Oncogene Serine/Threonine-Protein Kinase;

NCIt synonyms : RAF1 Kinase; RAF1; c-Raf; RAF-1 Protein; cRaf; EC 2.7.11.1; Proto-Oncogene c-RAF; Raf-1;

NCIt definition : RAF proto-oncogene serine/threonine-protein kinase (648 aa, 73 kDa) is encoded by the human RAF1 gene. This protein plays a role in cell fate and the activation of MAPK-dependent signaling.;

Details

Origin ID

C17484;

UMLS CUI

C4706023;

OMIM relation
- Raf1 protooncogene, serine/threonine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Raf1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- RAF1 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Sorafenib Tosylate [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cysteine-Rich Domain [NCIt concept]
- DAG/PE-Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Angiotensin II Signaling Pathway [NCIt concept]
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- CCR3 Signaling Pathway [NCIt concept]
- CXCR4 Signaling Pathway [NCIt concept]
- Cadmium Induction Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- Erk1/Erk2 MAPK Signaling Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Formyl Peptide Receptor 1 Signaling Pathway [NCIt concept]
- G-Protein Signaling Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- GPCR Signaling Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IGF1R Antiapoptosis Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL3 Signaling Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAP Kinase Activation Pathway [NCIt concept]
- MAP Kinase Downregulation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- Nerve Growth Factor Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Ras Signaling Pathway [NCIt concept]
- SRF Activation Pathway [NCIt concept]
- Sprouty Regulation of Tyrosine Kinase Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Avutometinib [NCIt concept]
- B-Raf/VEGFR-2 Inhibitor RAF265 [NCIt concept]
- Diazepinomicin [NCIt concept]
- Exarafenib [NCIt concept]
- Naporafenib [NCIt concept]
- Pan-RAF Inhibitor LY3009120 [NCIt concept]
- RAF Kinase Inhibitor XL281 [NCIt concept]
- Regorafenib [NCIt concept]
- Regorafenib Hydrate [NCIt concept]
- Rigosertib [NCIt concept]
- Sorafenib [NCIt concept]
- Sorafenib Tosylate [NCIt concept]
- Tovorafenib [NCIt concept]
- pan-RAF Inhibitor JZP815 [NCIt concept]
- pan-RAF Inhibitor QLH11906 [NCIt concept]
- pan-RAF Inhibitor TR128 [NCIt concept]
- pan-RAF Inhibitor XP-102 [NCIt concept]

Keyword's position in hierarchy(ies) :

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