Preferred Label : Avutometinib;
NCIt synonyms : Raf/MEK Inhibitor VS-6766;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine protein kinases Raf and mitogen-activated
protein kinase kinase (MAP2K, MAPK/ERK kinase, or MEK), with potential antineoplastic
activity. Upon oral administration, avutometinib specifically targets, binds to and
inhibits the kinase activities of Raf and MEK, resulting in the inhibition of Raf/MEK-mediated
signal transduction pathways. This results in the inhibition of Raf/MEK-dependent
tumor cell proliferation and survival. The RAS/RAF/MEK/extracellular signal-regulated
kinase (ERK) signaling pathway is often dysregulated in human cancers and plays a
key role in tumor cell proliferation, differentiation and survival.;
UNII : D0D4252V97;
InChIKey : LMMJFBMMJUMSJS-UHFFFAOYSA-N;
CAS number : 946128-88-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 946128-88-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : RO5126766; VS 6766; VS-6766; CH-5126766; R-7304; RG-7304; CKI-27; RG 7304;
Origin ID : C80060;
UMLS CUI : C5708875;
Semantic type(s)
- concept_is_in_subset
- has_target
