Mitogen-Activated Protein Kinase Kinase

Preferred Label : Mitogen-Activated Protein Kinase Kinase;

NCIt synonyms : MKK; MEK; MAP2K; MAPKK1; MAP Kinase Kinase; MAPKK; MEK1; MEK2;

NCIt definition : A family of dual-specific protein kinases that are activated through phosphorylation by mitogen-activated protein kinase kinase kinase (MAP3K, MAPKKK) proteins and can subsequently phosphorylate and activate mitogen-activated protein kinases (MAPK).;

Details

Origin ID

C105947;

UMLS CUI

C0169101;

Automatic exact mappings (from CISMeF team)
- MAP kinase kinase 1 [MeSH Descriptor]
- MAP kinase kinase 2 [MeSH Descriptor]
- Methyl acetone [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Mitogen-Activated protein kinase kinases [MeSH concept]
- Mitogen-Activated protein kinase kinases [MeSH Descriptor]
See also inter- (CISMeF)
- MAP kinase kinase activity [GO term]
- Mitogen-activated protein kinase kinase 1 [OMIM gene]
- Mitogen-activated protein kinase kinase 2 [OMIM gene]
- mitogen-activated protein kinase kinase 1 [ORDO Gene]
- mitogen-activated protein kinase kinase 2 [ORDO Gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Mitogen-Activated protein kinase kinases [MeSH Descriptor]
- Mitogen-Activated protein kinase kinases [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Kinase Family Gene [NCIt concept]
gene_product_has_biochemical_function
- Phosphotransferase [NCIt concept]
- Protein Kinase [NCIt concept]
gene_product_has_chemical_classification
- Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
is_target
- Avutometinib [NCIt concept]
- MEK Inhibitor PF-07799544 [NCIt concept]
- MEK inhibitor BI 3011441 [NCIt concept]
- Nedometinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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