Preferred Label : Nedometinib;
NCIt synonyms : NFX-179 Topical Gel; NFX-179 Gel; Topical MEK Inhibitor NFX-179; MEK Inhibitor NFX-179;
NCIt definition : A topical gel formulation composed of an inhibitor of mitogen-activated protein kinase
kinase (MAP2K; MAPKK; MEK), with potential antineoplastic activity. Upon topical administration,
nedometinib penetrates into the dermis of the skin where it specifically targets,
binds to and inhibits the catalytic activity of MEK, thereby inhibiting the activation
of MEK-dependent effector proteins including extracellular signal-regulated kinase
(ERK) and inhibits the proliferation of tumor cells in which the RAS/RAF/MEK/ERK signaling
pathway is overactivated. The threonine/tyrosine protein kinase MEK plays a key role
in the RAS/RAF/MEK/ERK signaling pathway, which is frequently upregulated in a variety
of tumor cell types and regulates key cellular activities including cell growth, proliferation,
survival, differentiation and apoptosis. Rapid degradation of NFX-179 upon reaching
the systemic circulation minimizes side effects caused by systemic exposure.;
UNII : K5T4I78IYZ;
CAS number : 2252314-46-6;
Molecule name : NFX 179; NFX-179;
NCI Metathesaurus CUI : CL1778587;
Origin ID : C186369;
UMLS CUI : C5853424;
Semantic type(s)
- concept_is_in_subset
- has_target
