Preferred Label : MEK Inhibitor PF-07799544;
NCIt definition : An orally bioavailable, brain penetrating inhibitor of mitogen-activated protein kinase
kinase (MAP2K; MAPKK; MEK), with potential antineoplastic activity. Upon oral administration,
MEK inhibitor PF-07799544 specifically targets, binds to and inhibits the catalytic
activity of MEK, thereby inhibiting the activation of MEK-dependent effector proteins,
including extracellular signal-regulated kinase (ERK), and inhibits the proliferation
of tumor cells in which the RAS/RAF/MEK/ERK signaling pathway is overactivated. The
threonine/tyrosine protein kinase MEK plays a key role in the RAS/RAF/MEK/ERK signaling
pathway, which is frequently upregulated in a variety of tumor cell types and regulates
key cellular activities including cell growth, proliferation, survival, differentiation
and apoptosis.;
Molecule name : ARRY-134; PF 07799544; ARRY 134; PF-07799544;
NCI Metathesaurus CUI : CL1912932;
Origin ID : C192683;
UMLS CUI : C5787279;
Semantic type(s)
- concept_is_in_subset
- has_target
