EPO Signaling Pathway

Preferred Label : EPO Signaling Pathway;

Alternative definition : BIOCARTA: Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes for any number of reasons. The signaling mechanism includes multimerization of the receptor upon ligand binding, activation of MAPK cascade, and phosphorylation and activation of Stat5. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_epoPathway;

Details

Origin ID

C39067;

UMLS CUI

C1512125;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- Casein Kinase II Subunit Alpha [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- Erythropoietin [NCIt concept]
- Erythropoietin Receptor [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 6 [NCIt concept]
pathway_has_gene_element
- CSNK2A1 wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- EPO wt Allele [NCIt concept]
- EPOR wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PTPN6 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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