Erythropoietin Receptor

Preferred Label : Erythropoietin Receptor;

NCIt synonyms : EPO-R; EPOR;

NCIt definition : Erythropoietin receptor (508 aa, 55 kDa) is encoded by the human EPOR gene. This protein is involved in signal transduction and erythroblast proliferation and differentiation.;

NCIt note : Erythropoietin receptor is a cell surface receptor that binds erythropoietin with high affinity and activates the JAK2 tyrosine kinase pathway.;

Details

Origin ID

C17295;

UMLS CUI

C5441744;

Currated CISMeF NLP mapping
- erythropoietin receptor (1-225) [MeSH concept]
- erythropoietin receptor (1-225) [MeSH Supplementary Concept]
- receptors, erythropoietin [MeSH Descriptor]
- receptors, erythropoietin [MeSH concept]
OMIM relation
- Erythropoietin receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptors, erythropoietin [MeSH concept]
- receptors, erythropoietin [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- EPOR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Darbepoetin Alfa [NCIt concept]
- Efepoetin Alfa [NCIt concept]
- Efparepoetin Alfa [NCIt concept]
- Epoetin Alfa [NCIt concept]
- Epoetin Beta [NCIt concept]
- Epoetin Delta [NCIt concept]
- Epoetin Zeta [NCIt concept]
- Idestopoetin Alfa [NCIt concept]
- Pegdarbepoetin Beta [NCIt concept]
- Peginesatide Acetate [NCIt concept]
- Pegol-sihematide Injection [NCIt concept]
- Pegzerepoetin Alfa [NCIt concept]
- Recombinant Erythropoietin [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- ITIM [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- Erythropoietin Neuroprotection Pathway [NCIt concept]
- Erythropoietin Signaling Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Colony Stimulating Factor Signaling Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Erythropoiesis [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Darbepoetin Alfa [NCIt concept]
- Epoetin Alfa [NCIt concept]

Keyword's position in hierarchy(ies) :

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