Erythropoietin Neuroprotection Pathway

Preferred Label : Erythropoietin Neuroprotection Pathway;

NCIt related terms : Erythropoietin mediated neuroprotection through NF-kB;

Alternative definition : BIOCARTA: Erythropoietin (Epo) is most commonly known as the cytokine secreted by the kidneys that stimulates red blood cell production and is used as a drug for the treatment of anemias. Epo is also secreted in the brain in response to hypoxia, such as ischemic stroke. Epo production in the brain is stimulated by the hypoxia-inducible transcription factor HIF-1 (see HIF pathway). Administration of Epo to the brain in rodents before hypoxic stress or other neuronal stresses is neuroprotective, preventing neuronal apoptosis. The erythropoietin receptor (EpoR) is known to associate with JAK kinases that phosphorylate and activate the STAT family of transcription factors. The neuroprotection by Epo involves cross-talk between Epo receptor and anti-apoptotic pathways through activation of NF-kB by the JAK2 kinase. Epo stimulates JAK2 phosphorylation of I-kB, releasing NF-kB to translocate into the nucleus and activate transcription of neuroprotective genes. Neuroprotective genes activated by NF-kB include the anti-oxidant enzyme manganese superoxide dismutase and calbindin-D28k. The erythropoietin receptor is also essential for proper brain development in mice. The absence of EpoR causes high levels of neuronal apoptosis in the developing mouse brain, further confirming the important role of Epo as a neuroprotective agent. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_eponfkbPathway;

Details

Origin ID

C39066;

UMLS CUI

C1516961;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Aryl Hydrocarbon Receptor Nuclear Translocator [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1 [NCIt concept]
- Erythropoietin [NCIt concept]
- Erythropoietin Receptor [NCIt concept]
- Hypoxia-Inducible Factor 1-Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Superoxide Dismutase [Mn], Mitochondrial [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
pathway_has_gene_element
- ARNT wt Allele [NCIt concept]
- CDKN1A wt Allele [NCIt concept]
- EPO wt Allele [NCIt concept]
- EPOR wt Allele [NCIt concept]
- HIF1A wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- SOD2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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