Hypoxia-Inducible Factor 1-Alpha

Preferred Label : Hypoxia-Inducible Factor 1-Alpha;

NCIt synonyms : HIF-1Alpha; HIF1A; Member of PAS Protein 1; ARNT Interacting Protein; PAS Domain-Containing Protein 8; bHLHe78; Class E Basic Helix-Loop-Helix Protein 78; Member of PAS Superfamily 1; Hypoxia-Inducible Factor1alpha; ARNT-Interacting Protein; Basic-Helix-Loop-Helix-PAS Protein MOP1; HIF-1-Alpha; Hypoxia-Inducible Factor 1, Alpha Subunit; Hypoxia-Inducible Factor-1 Alpha Subunit; HIF-1 Alpha;

NCIt definition : Hypoxia-inducible factor 1-alpha (826 aa, 93 kDa) is encoded by the human HIF1A gene. This protein plays a role in transcriptional regulation in response to hypoxia.;

NCIt note : Under normoxic conditions, HIF-1alpha is rapidly degraded, whereas hypoxia, CoCl(2), or desferroxamine promote protein stabilization, thus evoking its transcriptional activity.;

Details

Origin ID

C20214;

UMLS CUI

C1528322;

Currated CISMeF NLP mapping
- Hypoxia-Inducible factor 1, alpha subunit [MeSH concept]
- hypoxia-inducible factor 1, alpha subunit [MeSH Descriptor]
OMIM relation
- Hypoxia-inducible factor 1, alpha subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HIF1A protein, human [MeSH concept]
- HIF1A protein, human [MeSH Supplementary Concept]
- Hypoxia-Inducible factor 1, alpha subunit [MeSH concept]
- hypoxia-inducible factor 1, alpha subunit [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- HIF1A Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- BHLH Protein [NCIt concept]
- DNA Binding Protein [NCIt concept]
- Hypoxia Inducible Factor Family [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- Angiogenesis Pathway [NCIt concept]
- Erythropoietin Neuroprotection Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway [NCIt concept]
- Hypoxia-Inducible Factor Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- VEGFR1 Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_is_physical_part_of
- Hypoxia-Inducible Factor-1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cellular Stress [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968 [NCIt concept]
- HIF-1alpha Inhibitor PX-478 [NCIt concept]

Keyword's position in hierarchy(ies) :

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