" /> Hypoxia Inducible Factor Family - CISMeF





Preferred Label : Hypoxia Inducible Factor Family;

NCIt synonyms : Hypoxia Inducible Factor; HIF Family; HIF; HIF Factor; Hypoxia-Inducible Factor Family; Hypoxia-Inducible Factor;

NCIt definition : A family of basic helix-loop-helix heterodimeric transcription factors that activate gene expression when oxygen levels decrease in the cellular environment. Each HIF complex is comprised of an alpha subunit and beta subunit, which are encoded by separate genes.;

NCIt note : During normoxic conditions, the alpha subunits of HIF are hydroxylated at conserved proline residues by prolyl-hydroxylase enzymes. This modification promotes alpha subunit ubiquitination, which leads to proteasomal degradation. In hypoxic conditions, prolyl-hydroxylase activity is inhibited; therefore, the half-life of the alpha subunits are prolonged and they are able to dimerize with the appropriate beta subunit to regulate the expression of hypoxia-responsive genes.;

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15/05/2024


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