Aryl Hydrocarbon Receptor Nuclear Translocator

Preferred Label : Aryl Hydrocarbon Receptor Nuclear Translocator;

NCIt synonyms : HIF-1 Beta; Hypoxia-Inducible Factor 1 Beta; Dioxin Receptor, Nuclear Translocator; HIF-1Beta; HIF1-BETA; ARNT; HIF1BETA; ARNT Protein; Hypoxia-Inducible Factor 1, Beta Subunit; HIF1B; Class E Basic Helix-Loop-Helix Protein 2; Hypoxia-Inducible Factor 1-Beta; bHLHe2;

NCIt definition : Aryl hydrocarbon receptor nuclear translocator (789 aa, 87 kDa) is encoded by the human ARNT gene. This protein plays a role in transcriptional regulation, polycyclic aromatic hydrocarbon metabolism and DNA binding.;

NCIt note : Efficient DNA binding requires dimerization with another bHLH protein. (UniProt);

Details

Origin ID

C28553;

UMLS CUI

C1506870;

Currated CISMeF NLP mapping
- aryl hydrocarbon receptor nuclear translocator [MeSH Descriptor]
- aryl hydrocarbon receptor nuclear translocator [MeSH concept]
OMIM relation
- Aryl hydrocarbon receptor nuclear translocator [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ARNT protein, human [MeSH Supplementary Concept]
- ARNT protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ARNT Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- BHLH Protein [NCIt concept]
- DNA Binding Protein [NCIt concept]
- Hypoxia Inducible Factor Family [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- AHR Signal Transduction Pathway [NCIt concept]
- Angiogenesis Pathway [NCIt concept]
- Erythropoietin Neuroprotection Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- HIF-2-Alpha Transcription Factor Pathway [NCIt concept]
- Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway [NCIt concept]
- Hypoxia-Inducible Factor Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
gene_product_is_physical_part_of
- Hypoxia-Inducible Factor-1 [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Ligand Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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