AHR Signal Transduction Pathway

Preferred Label : AHR Signal Transduction Pathway;

Alternative definition : BIOCARTA: The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ah receptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase. The inactive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also referred to as AIP or ARA9). (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_acrPathway;

Details

Origin ID

C38972;

UMLS CUI

C1510689;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- AH Receptor-Interacting Protein [NCIt concept]
- Aryl Hydrocarbon Receptor [NCIt concept]
- Aryl Hydrocarbon Receptor Nuclear Translocator [NCIt concept]
- Heat Shock Protein HSP 90-Alpha [NCIt concept]
pathway_has_gene_element
- AHR wt Allele [NCIt concept]
- AIP wt Allele [NCIt concept]
- ARNT wt Allele [NCIt concept]
- HSP90AA1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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