Aryl Hydrocarbon Receptor

Preferred Label : Aryl Hydrocarbon Receptor;

NCIt synonyms : AhR; AH Receptor; Aromatic Hydrocarbon Receptor; AH-Receptor; bHLHe76; Class E Basic Helix-Loop-Helix Protein 76;

NCIt definition : Aryl hydrocarbon receptor (848 aa, 96 kDa) is encoded by the human AHR gene. This protein is involved in the regulation of apotosis, the cell cycle and xenobiotic-stimulated gene transcription.;

NCIt note : The aryl hydrocarbon receptor (AhR) is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. Many foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are ligands of AhR. Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AhR.;

Details

Origin ID

C17273;

UMLS CUI

C1312385;

Currated CISMeF NLP mapping
- receptors, aryl hydrocarbon [MeSH Descriptor]
- receptors, aryl hydrocarbon [MeSH concept]
OMIM relation
- Aryl hydrocarbon receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- AHR protein, human [MeSH concept]
- AHR protein, human [MeSH Supplementary Concept]
- receptors, aryl hydrocarbon [MeSH concept]
- receptors, aryl hydrocarbon [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AHR Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Cytoplasmic Receptor [NCIt concept]
- DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- AHR Signal Transduction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]
is_target
- Aryl Hydrocarbon Receptor Antagonist BAY2416964 [NCIt concept]
- Aryl Hydrocarbon Receptor Inhibitor IK-175 [NCIt concept]

Keyword's position in hierarchy(ies) :

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