Cytoplasmic Receptor

Preferred Label : Cytoplasmic Receptor;

NCIt synonyms : Receptor, Cytoplasmic;

NCIt definition : Cytoplasmic Receptors are selective binding proteins that mediate the physiologic effects of specific bound regulatory molecules, such as hormones that cause a conformational and functional change in the receptor molecule. Interaction of the ligand-bound receptor with target molecules is altered, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. Steroid receptors are cytoplasmic carriers that translocate to the nucleus upon ligand binding and regulate the expression of specific target genes.;

Details

Origin ID

C17670;

UMLS CUI

C0206587;

Automatic exact mappings (from CISMeF team)
- receptors, cytoplasmic and nuclear [MeSH Descriptor]
Biochemical function of gene products
- Aryl Hydrocarbon Receptor [NCIt concept]
Currated CISMeF NLP mapping
- receptors, cytoplasmic [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptors, cytoplasmic [MeSH concept]
gene_encodes_gene_product
- Cytoplasmic Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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