Preferred Label : Ilantimod;
NCIt synonyms : Aryl Hydrocarbon Receptor Inhibitor BAY2416964; AhR Inhibitor BAY2416964; AhR Antagonist BAY2416964; Aryl Hydrocarbon Receptor Antagonist BAY2416964;
NCIt definition : An orally available formulation containing a small molecule antagonist of the aryl
hydrocarbon receptor (AhR; class E basic helix-loop-helix protein 76; bHLHe76) with
potential immunomodulating and antineoplastic activities. Upon oral administration,
ilantimod specifically binds to AhR, inhibits AhR activation, and prevents AhR-mediated
signaling. Abrogation of AhR activation prevents the activation of immune-tolerant
dendritic cells (DCs) and regulatory T-cells (Tregs) in the tumor microenvironment
(TME). This may restore the immune response against tumor cells. AhR, a member of
the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors,
has important roles in regulating immunity and cellular differentiation. AhR can exhibit
both pro-oncogenic and tumor suppressor-like functions depending on the tumor type;
therefore, its expression may serve as a negative or positive prognostic factor.;
UNII : Y87V4WXQ4Z;
CAS number : 2242464-44-2;
Molecule name : BAY-2416964; BAY 2416964;
NCI Metathesaurus CUI : CL977437;
Origin ID : C164317;
UMLS CUI : C5236146;
Semantic type(s)
- concept_is_in_subset
- has_target
