Preferred Label : Aryl Hydrocarbon Receptor Antagonist BAY2416964;
NCIt synonyms : Aryl Hydrocarbon Receptor Inhibitor BAY2416964; AhR Inhibitor BAY2416964; AhR Antagonist BAY2416964;
NCIt definition : An orally available formulation containing a small molecule antagonist of the aryl
hydrocarbon receptor (AhR; class E basic helix-loop-helix protein 76; bHLHe76) with
potential immunomodulating and antineoplastic activities. Upon oral administration,
AhR antagonist BAY2416964 specifically binds to AhR, inhibits AhR activation, and
prevents AhR-mediated signaling. Abrogation of AhR activation prevents the activation
of immune-tolerant dendritic cells (DCs) and regulatory T-cells (Tregs) in the tumor
microenvironment (TME). This may restore the immune response against tumor cells.
AhR, a member of the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription
factors, has important roles in regulating immunity and cellular differentiation.
AhR can exhibit both pro-oncogenic and tumor suppressor-like functions depending on
the tumor type; therefore, its expression may serve as a negative or positive prognostic
factor.;
Molecule name : BAY-2416964; BAY 2416964;
NCI Metathesaurus CUI : CL977437;
Origin ID : C164317;
UMLS CUI : C5236146;
Semantic type(s)
- concept_is_in_subset
- has_target
