NCIt definition : Genes that code for transcription factors.;
NCIt note : Initiation of transcription from eukaryotic protein-coding genes is a complex process
requiring RNA polymerase II (Pol II) and a cadre of transcription factors. These factors
can be divided into 2 classes on the basis of their function: the general factors
that are required for transcription of all Pol II genes, and sequence-specific factors
that are required for regulating expression. The general transcription factors and
Pol II form a specific multiprotein complex near the transcription start site by interacting
with core promoter elements. The most common core element is the TATA box, typically
located 25-30 bp upstream of the transcriptional start site or initiator element.
Sequence-specific transcription factors that bind to DNA-sequence elements located
proximal and distal to the core promoter elements can dramatically enhance or repress
transcription. (from OMIM 189962);
Semantic type(s)