Upstream Stimulatory Factor 1

Preferred Label : Upstream Stimulatory Factor 1;

NCIt synonyms : USF1; Major Late Transcription Factor 1; bHLHb11; Major Late Transcription Factor; Class B Basic Helix-Loop-Helix Protein 11;

NCIt definition : Upstream stimulatory factor 1 (310 aa, 34 kDa) is encoded by the human USF1 gene. This protein plays a role in the positive regulation of gene transcription.;

NCIt note : Upstream stimulatory factor 1 is a bHLH transcription factor that binds to symmetrical E-box (5'-CACGTG-3') DNA sequences in viral and cellular promoters either as a homodimer or as a USF1/USF2 heterodimer (USF).;

Details

Origin ID

C38368;

UMLS CUI

C1451716;

OMIM relation
- Upstream transcription factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- USF1 protein, human [MeSH concept]
- USF1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- USF1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- p38-alpha and p38-beta Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Upstream Stimulatory Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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