Upstream Stimulatory Factor

Preferred Label : Upstream Stimulatory Factor;

NCIt synonyms : USF; Upstream Transcription Factor;

NCIt definition : The upstream stimulatory factor is a ubiquitously expressed cellular transcription factor that binds to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters. Purified USF consists of 2 related polypeptides of 43 and 44 kD encoded by USF1 and USF2, respectively. USF is known to be involved in the regulation of many gene with direct and indirect roles in cancer. (from OMIM and NCI);

Details

Origin ID

C17679;

UMLS CUI

C0076925;

Currated CISMeF NLP mapping
- upstream stimulatory factors [MeSH Descriptor]
- upstream stimulatory factors [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- upstream stimulatory factors [MeSH Descriptor]
- upstream stimulatory factors [MeSH concept]
gene_product_has_biochemical_function
- Transcription Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Regulation [NCIt concept]
has_gene_product_element
- Upstream Stimulatory Factor 1 [NCIt concept]
- Upstream Stimulatory Factor 2 [NCIt concept]
related_to_genetic_biomarker
- USF1 Gene [NCIt concept]
- USF2 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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