" /> BHLH Protein - CISMeF





Preferred Label : BHLH Protein;

NCIt synonyms : Basic HLH Protein; Basic Helix-Loop-Helix Protein;

NCIt definition : bHLH class proteins are sequence-specific DNA-binding proteins that contain a conserved 50-amino acid HLH domain consisting of two alpha-helices separated by a variable loop sequence, adjacent to a sequence that is highly enriched in basic amino acids. The HLH region mediates protein dimerization, while the basic region mediates sequence-specific DNA binding. Many bHLH proteins recognize a DNA sequence known as the E box. Class A bHLH proteins are ubiquitously expressed, while class B bHLH proteins are expressed in specific cell types. In general, class B proteins preferentially bind to DNA as heterodimers with class A proteins and function as transcriptional activators.;

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30/07/2025


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