BHLH Protein - CISMeF

Preferred Label : BHLH Protein;

NCIt synonyms : Basic HLH Protein; Basic Helix-Loop-Helix Protein;

NCIt definition : bHLH class proteins are sequence-specific DNA-binding proteins that contain a conserved 50-amino acid HLH domain consisting of two alpha-helices separated by a variable loop sequence, adjacent to a sequence that is highly enriched in basic amino acids. The HLH region mediates protein dimerization, while the basic region mediates sequence-specific DNA binding. Many bHLH proteins recognize a DNA sequence known as the E box. Class A bHLH proteins are ubiquitously expressed, while class B bHLH proteins are expressed in specific cell types. In general, class B proteins preferentially bind to DNA as heterodimers with class A proteins and function as transcriptional activators.;

Details

Origin ID

C17906;

UMLS CUI

C0288972;

Automatic exact mappings (from CISMeF team)
- basic Helix-Loop-Helix transcription factors [MeSH concept]
- basic helix-loop-helix transcription factors [MeSH Descriptor]
Biochemical function of gene products
- Aryl Hydrocarbon Receptor Nuclear Translocator [NCIt concept]
- Aryl Hydrocarbon Receptor Nuclear Translocator 2 [NCIt concept]
- Aryl Hydrocarbon Receptor Repressor [NCIt concept]
- Endothelial PAS Domain-Containing Protein 1 [NCIt concept]
- Hypoxia Inducible Factor Family [NCIt concept]
- Hypoxia-Inducible Factor 1-Alpha [NCIt concept]
- MAX Gene-Associated Protein [NCIt concept]
- Neurogenin-1 [NCIt concept]
- T-Cell Acute Lymphocytic Leukemia Protein 2 [NCIt concept]
- Transcription Factor E2-Alpha [NCIt concept]
- Transcription Factor E3 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- basic Helix-Loop-Helix transcription factors [MeSH concept]
- basic helix-loop-helix transcription factors [MeSH Descriptor]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- DNA Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Ligand Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
is_chemical_classification_of_gene_product
- Basic Helix-Loop-Helix ARNT-Like Protein 1 [NCIt concept]
- Basic Helix-Loop-Helix ARNT-Like Protein 2 [NCIt concept]
- Basic Helix-Loop-Helix Domain-Containing Protein USF3 [NCIt concept]
- Carbohydrate-Responsive Element-Binding Protein [NCIt concept]
- Circadian Locomoter Output Cycles Protein Kaput [NCIt concept]
- DNA-Binding Protein Inhibitor ID-1 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-2 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-3 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-4 [NCIt concept]
- Heart- and Neural Crest Derivatives-Expressed Protein 2 [NCIt concept]
- Neurogenic Differentiation Factor 1 [NCIt concept]
- Neurogenic Differentiation Factor 2 [NCIt concept]
- Neurogenic Differentiation Factor 4 [NCIt concept]
- Sterol Regulatory Element-Binding Protein 1 [NCIt concept]
- Transcription Cofactor HES-6 [NCIt concept]
- Transcription Factor HES-2 [NCIt concept]
- Transcription Factor HES-3 [NCIt concept]
- Transcription Factor HES-4 [NCIt concept]
- Upstream Stimulatory Factor 1 [NCIt concept]
- Upstream Stimulatory Factor 2 [NCIt concept]

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