DNA-Binding Protein Inhibitor ID-2

Preferred Label : DNA-Binding Protein Inhibitor ID-2;

NCIt synonyms : bHLHb26; ID2; Inhibitor of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein; Inhibitor of DNA Binding 2; Class B Basic Helix-Loop-Helix Protein 26; Inhibitor of Differentiation 2; ID2 Protein; Helix-Loop-Helix Protein ID2; DNA-Binding Protein Inhibitor ID2;

NCIt definition : DNA-binding protein inhibitor ID-2 (134 aa, 15 kDa) is encoded by the human ID2 gene. This protein is involved in the modulation of DNA binding by transcription factors.;

NCIt note : DNA-binding protein inhibitor ID-2 is an HLH protein, but lacks a basic DNA-binding domain. This protein heterodimerizes through the HLH domain with other bHLH transcription factors and inhibits DNA binding of those factors in a dominant-negative manner by suppressing their heterodimerization with functional partners.;

Details

Origin ID

C18168;

UMLS CUI

C0123156;

Automatic exact mappings (from CISMeF team)
- Inhibitor of dna binding 2 [OMIM gene]
- delta sleep-inducing peptide, N-Tyr- [MeSH Supplementary Concept]
- inhibitor of DNA binding 2 [HGNC gene]
- inhibitor of differentiation protein 2 [MeSH Descriptor]
- inhibitor of differentiation protein 2 [MeSH concept]
OMIM relation
- Inhibitor of dna binding 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ID2 protein, human [MeSH concept]
- ID2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ID2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Cell Cycle Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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