Basic Helix-Loop-Helix ARNT-Like Protein 1

Preferred Label : Basic Helix-Loop-Helix ARNT-Like Protein 1;

NCIt synonyms : PAS Domain-Containing Protein 3; Class E Basic Helix-Loop-Helix Protein 5; Member of PAS Superfamily 3; bHLHe5; Member of PAS Protein 3; BHLH-PAS Protein JAP3; Brain and Muscle ARNT-Like 1; Brain and Muscle ARNT-Like Protein 1; Basic-Helix-Loop-Helix-PAS Protein MOP3; ARNTL; BMAL1B; BMAL1; Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 1; Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein;

NCIt definition : Basic helix-loop-helix ARNT-like protein 1 (626 aa, 69 kDa) is encoded by the human BMAL1 gene. This protein is involved in the activation of gene transcription that mediates circadian rhythm.;

NCIt note : Aryl hydrocarbon receptor nuclear translocator-like protein 1 forms a heterodimer with circadian locomoter output cycles protein kaput; the heterodimer can bind to E-box enhancer elements (5'-CACGTG-3'). The interaction of the heterodimeric complex with cryptochrome or period family transcriptional repressors inhibits the ability of the heterodimer to activate gene transcription. (UniProt); UniProt considers the BMAL1B form of basic helix-loop-helix ARNT-like protein 1 the canonical form.;

Details

Origin ID

C119694;

UMLS CUI

C1431330;

Automatic exact mappings (from CISMeF team)
- ARNTL transcription factors [MeSH Descriptor]
- Brain and muscle arnt-like protein 1 [OMIM gene]
- aryl hydrocarbon receptor nuclear translocator-like 1 protein [MeSH concept]
- basic helix-loop-helix ARNT like 1 [HGNC gene]
OMIM relation
- Brain and muscle arnt-like protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BMAL1 protein, human [MeSH Supplementary Concept]
- BMAL1 protein, human [MeSH concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- BMAL1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- Circadian Rhythm Pathway BioCarta [NCIt concept]
- Circadian Rhythm Pathway KEGG [NCIt concept]
- Circadian Rhythm Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Biological Rhythm [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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