Aryl Hydrocarbon Receptor Repressor

Preferred Label : Aryl Hydrocarbon Receptor Repressor;

NCIt synonyms : Arylhydrocarbon Receptor Repressor; Aryl Hydrocarbon Hydroxylase Regulator; Aryl-Hydrocarbon Receptor Repressor; Aryl Hydrocarbon Receptor Regulator; Dioxin Receptor Repressor; bHLHe77; Class E Basic Helix-Loop-Helix Protein 77; AhRR;

NCIt definition : Aryl hydrocarbon receptor repressor (701 aa, 76 kDa) is encoded by the human AHRR gene. This protein plays a role in the downregulation of aryl hydrocarbon receptor responsive gene expression and the cellular response to polycyclic aromatic hydrocarbons, including dioxin.;

NCIt note : Aryl hydrocarbon receptor repressor forms a heterodimer with aryl hydrocarbon receptor nuclear translocator. This dimer subsequently binds to xenobiotic response element (XRE) and represses gene expression. (UniProt);

Details

Origin ID

C177421;

UMLS CUI

C5444319;

OMIM relation
- Arylhydrocarbon receptor repressor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- AHRR Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- BHLH Protein [NCIt concept]
- DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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