Heart- and Neural Crest Derivatives-Expressed Protein 2

Preferred Label : Heart- and Neural Crest Derivatives-Expressed Protein 2;

NCIt synonyms : Class A Basic Helix-Loop-Helix Protein 26; Basic Helix-Loop-Helix Transcription Factor HAND2; dHAND; Deciduum, Heart, Autonomic Nervous System and Neural Crest Derivatives-Expressed Protein 2; bHLHa26; HAND2;

NCIt definition : Heart- and neural crest derivatives-expressed protein 2 (217 aa, 24 kDa) is encoded by the human HAND2 gene. This protein plays a role in the regulation of gene expression during heart development.;

NCIt note : Heart- and neural crest derivatives-expressed protein 2 binds the DNA E-box consensus sequence 5'-CANNTG-3'. (UniProt);

Details

Origin ID

C102792;

UMLS CUI

C3537326;

OMIM relation
- Heart- and neural crest derivatives-expressed 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- HAND2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_expressed_in_tissue
- Fetal Heart [NCIt concept]
- Heart [NCIt concept]
gene_product_has_associated_anatomy
- Chromatin [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- NFAT Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Organogenesis [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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