Circadian Locomoter Output Cycles Protein Kaput

Preferred Label : Circadian Locomoter Output Cycles Protein Kaput;

NCIt synonyms : Circadian Locomoter Output Cycles Kaput Protein; Class E Basic Helix-Loop-Helix Protein 8; EC 2.3.1.48; hCLOCK; Clock Homolog; CLOCK; bHLHe8;

NCIt definition : Circadian locomoter output cycles protein kaput (846 aa, 95 kDa) is encoded by the human CLOCK gene. This protein plays a role in the modulation of histone acetylation that regulates both gene expression and circadian rhythms.;

NCIt note : Circadian locomoter output cycles protein kaput forms a heterodimer with either aryl hydrocarbon receptor nuclear translocator-like protein 1 or 2; the heterodimer can bind to E-box enhancer elements (5'-CACGTG-3'). The interaction of the heterodimeric complex with cryptochrome or period family transcriptional repressor proteins inhibits the ability of the heterodimer to activate gene transcription. (UniProt);

Details

Origin ID

C119691;

UMLS CUI

C1743089;

OMIM relation
- Circadian locomotor output cycles kaput [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CLOCK protein, human [MeSH Supplementary Concept]
- CLOCK protein, human [MeSH concept]
gene_encodes_gene_product
- CLOCK Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- All Sites [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- Circadian Rhythm Pathway BioCarta [NCIt concept]
- Circadian Rhythm Pathway KEGG [NCIt concept]
- Circadian Rhythm Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Biological Rhythm [NCIt concept]
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- Histone Acetylation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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