" /> Circadian Locomoter Output Cycles Protein Kaput - CISMeF





Preferred Label : Circadian Locomoter Output Cycles Protein Kaput;

NCIt synonyms : Circadian Locomoter Output Cycles Kaput Protein; Class E Basic Helix-Loop-Helix Protein 8; EC 2.3.1.48; hCLOCK; Clock Homolog; CLOCK; bHLHe8;

NCIt definition : Circadian locomoter output cycles protein kaput (846 aa, 95 kDa) is encoded by the human CLOCK gene. This protein plays a role in the modulation of histone acetylation that regulates both gene expression and circadian rhythms.;

NCIt note : Circadian locomoter output cycles protein kaput forms a heterodimer with either aryl hydrocarbon receptor nuclear translocator-like protein 1 or 2; the heterodimer can bind to E-box enhancer elements (5'-CACGTG-3'). The interaction of the heterodimeric complex with cryptochrome or period family transcriptional repressor proteins inhibits the ability of the heterodimer to activate gene transcription. (UniProt);

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24/07/2025


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