Transcription Factor HES-4

Preferred Label : Transcription Factor HES-4;

NCIt synonyms : HES4; hHES4; Class B Basic Helix-Loop-Helix Protein 42; bHLHb42; bHLH Factor Hes4; Hairy and Enhancer of Split 4;

NCIt definition : Transcription factor HES-4 (221 aa, 24 kDa) is encoded by the human HES4 gene. This protein plays a role in transcriptional repression.;

NCIt note : The transcriptional repression activity of transcription factor HES-4 requires formation of a complex with a corepressor protein of the Groucho/TLE family. (UniProt); Transcription factor HES-4 binds to DNA on N-box motifs: 5'-CACNAG-3'. (UniProt);

Details

Origin ID

C104259;

UMLS CUI

C3539876;

OMIM relation
- Hes family bhlh transcription factor 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HES4 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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