Sterol Regulatory Element-Binding Protein 1

Preferred Label : Sterol Regulatory Element-Binding Protein 1;

NCIt synonyms : SREBF1; Sterol Regulatory Element-Binding Transcription Factor 1; bHLHd1; SREBP-1; Class D Basic Helix-Loop-Helix Protein 1;

NCIt definition : Sterol regulatory element-binding protein 1 (1147 aa, 122 kDa) is encoded by the human SREBF1 gene. This protein is involved in both transcriptional activation and cholesterol homeostasis.;

NCIt note : The sterol regulatory element-binding protein 1 is complexed with sterol regulatory element-binding protein cleavage-activating protein in the ER. When cholesterol levels are low, the complex is exported to the Golgi complex where sterol regulatory element-binding protein 1 is cleaved sequentially by site-1 and site-2 proteases. The first cleavage the by site-1 protease occurs within the luminal loop, the second cleavage by the site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. After site-2 cleavage, sterol regulatory element-binding protein 1 can be imported into the nucleus where it can activate gene transcription. (UniProt); Sterol regulatory element-binding protein 1 binds to both the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') and the E-box motif (5'-ATCACGTGA-3'). (UniProt);

Details

Origin ID

C105087;

UMLS CUI

C1528373;

OMIM relation
- Sterol regulatory element-binding transcription factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SREBF1 protein, human [MeSH concept]
- SREBF1 protein, human [MeSH Supplementary Concept]
- sterol regulatory element binding protein 1 [MeSH concept]
- sterol regulatory element binding protein 1 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SREBF1 Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
- Membrane of the Golgi Apparatus [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Lipid Metabolic Process [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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