Caspase Cascade Pathway

Preferred Label : Caspase Cascade Pathway;

NCIt related terms : Caspase Cascade in Apoptosis;

Alternative definition : BIOCARTA: Apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, and cytotoxic T cells. Caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. The caspases at the upper end of the cascade include caspase-8 and caspase-9. Caspase-8 is the initial caspase involved in response to receptors with a death domain like FAS. The mitochondrial stress pathway begins with the release of cytochrome c from mitochondria, which then interacts with Apaf-1, causing self-cleavage and activation of caspase-9. Caspase-3, -6, and -7 are downstream caspases that are activated by the upstream proteases and act themselves to cleave cellular targets. Granzyme B and perforin proteins released by cytotoxic T cells induce apoptosis in target cells, forming transmembrane pores, and triggering apoptosis, perhaps through cleavage of caspases, although caspase-independent mechanisms of Granzyme B mediated apoptosis have been suggested. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_caspasePathway;

Details

Origin ID

C39014;

UMLS CUI

C1516311;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Activated Caspase-3 [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 2 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 3 [NCIt concept]
- Caspase-1 [NCIt concept]
- Caspase-10 [NCIt concept]
- Caspase-2 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-4 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- E3 Ubiquitin-Protein Ligase XIAP [NCIt concept]
- Granzyme B [NCIt concept]
- Lamin-A/C [NCIt concept]
- Lamin-B1 [NCIt concept]
- Perforin-1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Sterol Regulatory Element-Binding Protein 1 [NCIt concept]
pathway_has_gene_element
- APAF1 wt Allele [NCIt concept]
- BIRC2 wt Allele [NCIt concept]
- BIRC3 wt Allele [NCIt concept]
- CASP1 wt Allele [NCIt concept]
- CASP10 wt Allele [NCIt concept]
- CASP2 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP4 wt Allele [NCIt concept]
- CASP6 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- DFFB wt Allele [NCIt concept]
- GZMB wt Allele [NCIt concept]
- LMNA wt Allele [NCIt concept]
- LMNB1 wt Allele [NCIt concept]
- PARP1 wt Allele [NCIt concept]
- PRF1 wt Allele [NCIt concept]
- SREBF1 wt Allele [NCIt concept]
- XIAP wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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