" /> Poly [ADP-Ribose] Polymerase 1 - CISMeF





Preferred Label : Poly [ADP-Ribose] Polymerase 1;

NCIt synonyms : Poly(ADP-Ribose) Synthetase; Poly(ADP-Ribosyl)Transferase; ADP-Ribosyltransferase NAD( ); ARTD1; Poly[ADP-Ribose] Synthase 1; ADPRT 1; Poly(ADP Ribose) Polymerase; Poly ADP ribose Polymerase; EC 2.4.2.30; ADP-Ribosyltransferase Diphtheria Toxin-Like 1; NAD( ) ADP-Ribosyltransferase 1; ADP-Ribosyltransferase; Poly(ADP Ribose) Polymerase 1; PARP1; Poly (ADP Ribose) Polymerase 1; PARP-1;

NCIt related terms : PARP; poly (ADP-ribose) polymerase; poly(ADP-ribose) polymerase-1;

NCIt definition : Poly [ADP-ribose] polymerase 1 (1013aa, 113 kDa) is encoded by the human PARP1 gene. This protein is involved in poly ADP-ribosylation and in the regulation of various cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage.;

Alternative definition : NCI-GLOSS: An enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. Inhibitors of PARP-1 are being studied in the treatment of cancer.;

NCIt note : Poly [ADP ribose] polymerase 1 is a cytosolic protein, and when activated is cleaved into two fragments of 89kd and 24kd.;

Codes from synonyms : CDR0000658047; CDR0000658048; CDR0000653135; CDR0000653136;

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22/04/2024


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