Veliparib - CISMeF

Preferred Label : Veliparib;

NCIt synonyms : 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide;

NCIt related terms : PARP-1 inhibitor ABT-888; ABT-888;

NCIt definition : A poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. ABT-888 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor.;

UNII : 01O4K0631N;

InChIKey : JNAHVYVRKWKWKQ-CYBMUJFWSA-N;

CAS number : 912444-00-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 912444-00-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ABT-888;

Chemical formula : C13H16N4O;

NSC code : 737664;

ChEBI ID : CHEBI:62880;

Codes from synonyms : CDR0000660981; CDR0000524260; CDR0000674055; 531;

Details

Origin ID

C60768;

UMLS CUI

C1958300;

Currated CISMeF NLP mapping
- veliparib [MeSH concept]
- veliparib [MeSH Supplementary Concept]
Manual BTNT mappings - CISMeF
- veliparib [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- veliparib [ATC Code]
- veliparib [MeSH concept]
- veliparib [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Temozolomide/Veliparib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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