NCIt definition : An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose)
polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration,
NOV1401 selectively binds to PARP-1 and -2, thereby preventing PARP-1 and -2-mediated
DNA repair. This promotes genetic instability and enhances the accumulation of single
and double strand DNA breaks, ultimately leading to apoptosis. The PARP family of
proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is
activated by single-strand DNA (ssDNA) breaks.;