" /> Senaparib - CISMeF





Preferred Label : Senaparib;

NCIt synonyms : PARP 1/2 Inhibitor IMP4297;

NCIt definition : An orally bioavailable inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, senaparib selectively binds to PARP 1 and 2 and prevents PARP-mediated DNA repair of single-strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.;

UNII : MNZ4OP95CF;

InChIKey : VBTUJTGLLREMNW-UHFFFAOYSA-N;

CAS number : 1401682-78-7;

Molecule name : IMP 4297; IMP-4297;

NCI Metathesaurus CUI : CL972916;

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17/06/2025


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