NCIt definition : An orally available small molecule inhibitor of the nuclear enzyme poly (ADP-ribose)
polymerase (PARP) 7, with potential immunomodulating and antineoplastic activities.
Upon oral administration,atamparib selectively binds to PARP7 and restores interferon
(type 1) signaling. This may lead to the induction of both innate and adaptive immune
responses, and the inhibition of tumor growth and proliferation. PARP catalyzes post-translational
ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair
damaged DNA.;
UNII : B1MW2ME77A;
CAS number : 2381037-82-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2381037-82-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;