Base Excision Repair

Preferred Label : Base Excision Repair;

NCIt synonyms : DNA Base Excision Repair; BER;

NCIt definition : Initiation of DNA base excision repair (BER) involves a DNA glycosylase that binds the altered deoxynucleoside in an extrahelical position and catalyzes cleavage of the base-sugar bond. Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation.;

Détails

Origin ID

C20212;

UMLS CUI

C1158530;

Automatic exact mappings (from CISMeF team)
- Excision Repair [MeSH Descriptor]
- Fibers [LOINC component]
- Vegetable fibers [LOINC component]
- dna repair [MeSH Descriptor]
- optical fibers [MeSH Descriptor]
Currated CISMeF NLP mapping
- base excision repair [MeSH concept]
- base-excision repair [GO term]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- base excision repair [MeSH concept]
- base-excision repair [GO term]
biological_process_involves_gene_product
- Adenine DNA Glycosylase [NCIt concept]
- DNA Ligase 3 [NCIt concept]
- DNA Polymerase Beta [NCIt concept]
- DNA Polymerase Subunit Gamma-1 [NCIt concept]
- DNA-(Apurinic or Apyrimidinic Site) Lyase 2 [NCIt concept]
- Endonuclease 8-Like 1 [NCIt concept]
- Endonuclease 8-Like 3 [NCIt concept]
- Endonuclease III-Like Protein 1 [NCIt concept]
- Flap Endonuclease 1 [NCIt concept]
- N-Glycosylase/DNA Lyase [NCIt concept]
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 2 [NCIt concept]
- Protein FAM168A [NCIt concept]
- Protein Mono-ADP-Ribosyltransferase PARP3 [NCIt concept]
- Single-Strand Selective Monofunctional Uracil DNA Glycosylase [NCIt concept]
- Uracil-DNA Glycosylase [NCIt concept]
- Uracil-DNA Glycosylase Isoform 1 [NCIt concept]
- Werner Syndrome ATP-Dependent Helicase [NCIt concept]
biological_process_is_part_of_process
- Cell Survival [NCIt concept]
biological_process_results_from_biological_process
- Abasic Site Formation [NCIt concept]
- Formation of Apurinic Site [NCIt concept]
- Formation of Apyrimidine Site [NCIt concept]
- Formation of Bistrand Abasic Site [NCIt concept]
process_involves_gene
- APEX2 Gene [NCIt concept]
- APEX2 wt Allele [NCIt concept]
- FAM168A Gene [NCIt concept]
- FAM168A wt Allele [NCIt concept]
- FEN1 Gene [NCIt concept]
- FEN1 wt Allele [NCIt concept]
- LIG3 Gene [NCIt concept]
- LIG3 wt Allele [NCIt concept]
- NEIL1 Gene [NCIt concept]
- NEIL1 wt Allele [NCIt concept]
- NEIL3 Gene [NCIt concept]
- NEIL3 wt Allele [NCIt concept]
- NTHL1 Gene [NCIt concept]
- NTHL1 wt Allele [NCIt concept]
- OGG1 Gene [NCIt concept]
- OGG1 wt Allele [NCIt concept]
- PARP1 Gene [NCIt concept]
- PARP1 wt Allele [NCIt concept]
- PARP2 Gene [NCIt concept]
- PARP2 wt Allele [NCIt concept]
- PARP3 Gene [NCIt concept]
- PARP3 wt Allele [NCIt concept]
- POLB Gene [NCIt concept]
- POLB wt Allele [NCIt concept]
- POLG Gene [NCIt concept]
- POLG wt Allele [NCIt concept]
- SMUG1 Gene [NCIt concept]
- SMUG1 wt Allele [NCIt concept]
- UNG Gene [NCIt concept]
- UNG wt Allele [NCIt concept]
- WRN Gene [NCIt concept]
- WRN wt Allele [NCIt concept]

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