Werner Syndrome ATP-Dependent Helicase

Preferred Label : Werner Syndrome ATP-Dependent Helicase;

NCIt synonyms : Werner Syndrome Protein; WRN; Exonuclease WRN; EC 3.6.4.12; RecQ3; DNA Helicase, RecQ-Like Type 3; EC 3.1.-.-; RecQ Protein-Like 2; WRN Protein;

NCIt definition : Werner syndrome ATP-dependent helicase (1432 aa, 162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP-dependent DNA-helicase activity and 3'- 5' exonuclease activity towards double-stranded DNA with a 5'-overhang.;

Details

Origin ID

C20316;

UMLS CUI

C0388246;

OMIM relation
- Recq protein-like 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- WRN protein, human [MeSH concept]
- WRN protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- WRN Gene [NCIt concept]
gene_product_has_biochemical_function
- 3'-5' Exonuclease [NCIt concept]
- ATPase [NCIt concept]
- DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Telomerase Regulation Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Werner Syndrome [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Base Excision Repair [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Double Strand Break Repair [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]
is_target
- Werner Syndrome Helicase Inhibitor [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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