3'-5' Exonuclease

Preferred Label : 3'-5' Exonuclease;

NCIt synonyms : Three Prime-Five Prime Exonuclease;

NCIt definition : Three Prime-Five Prime Exonucleases prefer mismatched 3-prime termini, catalyze nucleoside monophosphate excision from 3-prime DNA termini and may be a DNA polymerase III subunit, which does not have intrinsic exonuclease activity. 3-prime terminal nucleotide excision from DNA is required to generate termini for subsequent DNA metabolic pathways.;

Details

Origin ID

C21546;

UMLS CUI

C0950448;

Automatic exact mappings (from CISMeF team)
- Phosphodiesterase I (substance) [SNOMED CT concept]
- Spleen exonuclease (substance) [SNOMED CT concept]
- exodeoxyribonuclease v [MeSH Descriptor]
- exonucleases [MeSH Descriptor]
- phosphodiesterase i [MeSH Descriptor]
- spleen exonuclease [MeSH Supplementary Concept]
Biochemical function of gene products
- Cell Cycle Checkpoint Control Protein RAD9A [NCIt concept]
- Cellular Tumor Antigen p53 [NCIt concept]
- DIS3-Like Exonuclease 2 [NCIt concept]
- DNA Polymerase Subunit Gamma-1 [NCIt concept]
- DNA-(Apurinic or Apyrimidinic Site) Lyase [NCIt concept]
- Exosome Complex Exonuclease RRP44 [NCIt concept]
- Exosome Component 10 [NCIt concept]
- Polyribonucleotide Nucleotidyltransferase 1, Mitochondrial [NCIt concept]
- Three Prime Repair Exonuclease 1 [NCIt concept]
- Three Prime Repair Exonuclease 2 [NCIt concept]
- U6 snRNA Phosphodiesterase [NCIt concept]
- Werner Syndrome ATP-Dependent Helicase [NCIt concept]
Currated CISMeF NLP mapping
- 3'-5'-Exonucleases [MeSH concept]
- 5'-3'-Exonucleases [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 3'-5'-Exonucleases [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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