Three Prime Repair Exonuclease 1

Preferred Label : Three Prime Repair Exonuclease 1;

NCIt synonyms : 3'-5' Exonuclease TREX1; 3' Repair Exonuclease 1; Deoxyribonuclease III; DNase III; DRN3; Three Prime Repair Exonuclease-1; 3 Prime Repair Exonuclease 1; Deoxyribonuclease III, DnaQ/MutD (E. coli)-Like; TREX1; EC 3.1.11.2;

NCIt definition : Three prime repair exonuclease 1 (369 aa, 39 kDa) is encoded by the human TREX1 gene. This protein is involved in DNA mismatch repair.;

NCIt note : It was originally thought that three prime repair exonuclease 1 and ATR-interacting protein were encoded by alternatively spliced transcripts from the same gene. They are now considered to be products of neighboring genes.;

Détails

Origin ID

C21547;

UMLS CUI

C1432808;

Currated CISMeF NLP mapping
- three prime repair exonuclease 1 [MeSH concept]
- three prime repair exonuclease 1 [MeSH Supplementary Concept]
OMIM relation
- 3-prime repair exonuclease 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TREX1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- TREX1 Gene [NCIt concept]
gene_product_has_biochemical_function
- 3'-5' Exonuclease [NCIt concept]
- Hydrolase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cancer Susceptibility Pathway [NCIt concept]
- Cytosolic DNA-Sensing Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- DNA Recombination Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Hydrolysis [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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