Hydrolase - CISMeF

Preferred Label : Hydrolase;

NCIt synonyms : Hydrolases; EC 3;

NCIt definition : Enzymes (EC class 3) cleaving substrates with addition of H2O at the point of cleavage; e.g., esterases, phosphatases, nucleases, peptidases. SYN hydrolyzing enzymes.;

Details

Origin ID

C16701;

UMLS CUI

C0020289;

Automatic exact mappings (from CISMeF team)
- Hydrolase (disposition) [SNOMED CT concept]
- Hydrolases [PASCAL theme]
Biochemical function of gene products
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Epsilon-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 [NCIt concept]
- 2-5A-Dependent Ribonuclease [NCIt concept]
- 3'-5' Exonuclease [NCIt concept]
- 5' Exonuclease Apollo [NCIt concept]
- 5'-3' Exonuclease [NCIt concept]
- 5'-3' Exoribonuclease 1 [NCIt concept]
- 5'-3' Exoribonuclease 2 [NCIt concept]
- 5'-Nucleotidase [NCIt concept]
- 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 [NCIt concept]
- 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 [NCIt concept]
- 85 kDa Calcium-Independent Phospholipase A2 [NCIt concept]
- ACP5 Gene Product [NCIt concept]
- Acetylcholinesterase [NCIt concept]
- Acyl-Coenzyme A Thioesterase THEM4 [NCIt concept]
- Acyl-Protein Thioesterase 1 [NCIt concept]
- Alkaline DNase [NCIt concept]
- Alkaline Phosphatase [NCIt concept]
- Alkaline Phosphatase, Germ Cell Type [NCIt concept]
- Alkaline Phosphatase, Placental Type [NCIt concept]
- Alkaline Phosphatase, Tissue-Nonspecific Isozyme [NCIt concept]
- Aryldialkylphosphatase [NCIt concept]
- Arylesterase [NCIt concept]
- Arylsulfatase A [NCIt concept]
- Auxilin [NCIt concept]
- Beta-Lactamase [NCIt concept]
- CD45RA [NCIt concept]
- CD45RB [NCIt concept]
- CD45RC [NCIt concept]
- CD45RO [NCIt concept]
- CTD Nuclear Envelope Phosphatase 1 [NCIt concept]
- Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2 [NCIt concept]
- Cell Cycle Checkpoint Control Protein RAD9A [NCIt concept]
- Cholinesterase [NCIt concept]
- Class II AP Endonuclease [NCIt concept]
- Cocaine Esterase [NCIt concept]
- Cone cGMP-Specific 3',5'-Cyclic Phosphodiesterase Subunit Alpha' [NCIt concept]
- Crossover Junction Endonuclease MUS81 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 3 [NCIt concept]
- Cytosolic 5'-Nucleotidase 1A [NCIt concept]
- Cytosolic 5'-Nucleotidase 3A [NCIt concept]
- Cytosolic Phospholipase A2 [NCIt concept]
- Cytosolic Phospholipase A2 Beta [NCIt concept]
- Cytosolic Phospholipase A2 Delta [NCIt concept]
- Cytosolic Phospholipase A2 Gamma [NCIt concept]
- Cytosolic Purine 5'-Nucleotidase [NCIt concept]
- DIS3-Like Exonuclease 2 [NCIt concept]
- DNA Annealing Helicase and Endonuclease ZRANB3 [NCIt concept]
- DNA Endonuclease RBBP8 [NCIt concept]
- DNA Exonuclease [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- DNA Repair Endonuclease [NCIt concept]
- DNA Repair Protein RAD51 Homolog 3 [NCIt concept]
- DNA Replication ATP-Dependent Helicase/Nuclease DNA2 [NCIt concept]
- DNA-(Apurinic or Apyrimidinic Site) Lyase [NCIt concept]
- DNA-(Apurinic or Apyrimidinic Site) Lyase 2 [NCIt concept]
- Deoxyribonuclease [NCIt concept]
- Dual Specificity Protein Phosphatase 1 [NCIt concept]
- Dual Specificity Protein Phosphatase 10 [NCIt concept]
- Dual Specificity Protein Phosphatase 22 [NCIt concept]
- Dual Specificity Protein Phosphatase 3 [NCIt concept]
- Dual Specificity Protein Phosphatase 4 [NCIt concept]
- Dual Specificity Protein Phosphatase 5 [NCIt concept]
- Dual Specificity Protein Phosphatase 6 [NCIt concept]
- Dual-Specificity Phosphoprotein Phosphatase [NCIt concept]
- Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 [NCIt concept]
- Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 [NCIt concept]
- Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 [NCIt concept]
- Endoribonuclease [NCIt concept]
- Endoribonuclease Dicer [NCIt concept]
- Endoribonuclease ZC3H12A [NCIt concept]
- Endothelial Lipase [NCIt concept]
- Eosinophil Lysophospholipase [NCIt concept]
- Esterase [NCIt concept]
- Exonuclease [NCIt concept]
- Exosome Complex Exonuclease RRP44 [NCIt concept]
- Exosome Component 10 [NCIt concept]
- Exosome Component 9 [NCIt concept]
- Extracellular Sulfatase Sulf-2 [NCIt concept]
- Eyes Absent Homolog 1 [NCIt concept]
- Fanconi-Associated Nuclease 1 [NCIt concept]
- Fatty Acid Synthase [NCIt concept]
- Flap Endonuclease 1 [NCIt concept]
- Flap Endonuclease GEN Homolog 1 [NCIt concept]
- Fructose-1,6-Bisphosphatase 1 [NCIt concept]
- GDH/6PGL Endoplasmic Bifunctional Protein [NCIt concept]
- Galactoside-Binding Soluble Lectin 13 [NCIt concept]
- Gastric Triacylglycerol Lipase [NCIt concept]
- Glucose-6-Phosphatase 3 [NCIt concept]
- Glutaminase Family [NCIt concept]
- Hepatic Triacylglycerol Lipase [NCIt concept]
- High Affinity cAMP-Specific and IBMX-Insensitive 3',5'-Cyclic Phosphodiesterase 8B [NCIt concept]
- High Affinity cGMP-Specific 3',5'-Cyclic Phosphodiesterase 9A [NCIt concept]
- INPP5D Gene Product [NCIt concept]
- Iduronate 2-Sulfatase [NCIt concept]
- Inositol Polyphosphate 4-Phosphatase Type II [NCIt concept]
- Inositol Polyphosphate 5-Phosphatase OCRL [NCIt concept]
- Inositol Polyphosphate-4-Phosphatase Type I A [NCIt concept]
- Lipase [NCIt concept]
- Lipoprotein Lipase [NCIt concept]
- Liver Carboxylesterase 1 [NCIt concept]
- Low Molecular Weight Phosphotyrosine Protein Phosphatase [NCIt concept]
- Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase [NCIt concept]
- Lysosomal Acid Phosphatase [NCIt concept]
- M-Phase Inducer Phosphatase 1 [NCIt concept]
- M-Phase Inducer Phosphatase 2 [NCIt concept]
- M-Phase Inducer Phosphatase 3 [NCIt concept]
- Mismatch Repair Endonuclease PMS2 [NCIt concept]
- Monoacylglycerol Lipase ABHD12 [NCIt concept]
- Myotubularin [NCIt concept]
- Myotubularin-Related Protein 1 [NCIt concept]
- Myotubularin-Related Protein 2 [NCIt concept]
- N-Acetylgalactosamine-6-Sulfatase [NCIt concept]
- NEDD4-Binding Protein 2 [NCIt concept]
- Non-Receptor Type Protein Tyrosine Phosphatase [NCIt concept]
- PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 1 [NCIt concept]
- PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 2 [NCIt concept]
- PTPRC Gene Product [NCIt concept]
- PTPRE Gene Product [NCIt concept]
- Palmitoyl-Protein Thioesterase 1 [NCIt concept]
- Pancreatic Triacylglycerol Lipase [NCIt concept]
- Phosphatase [NCIt concept]
- Phosphatidate Phosphatase LPIN2 [NCIt concept]
- Phosphatidylcholine-Sterol Acyltransferase [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 Isoform 3 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 2 [NCIt concept]
- Phosphoglycolate Phosphatase [NCIt concept]
- Phospholipase [NCIt concept]
- Phospholipase A and Acyltransferase 1 [NCIt concept]
- Phospholipase A and Acyltransferase 4 [NCIt concept]
- Phospholipase A2 [NCIt concept]
- Phospholipase A2, Membrane Associated [NCIt concept]
- Phospholipid Phosphatase 1 [NCIt concept]
- Phospholipid Phosphatase 3 [NCIt concept]
- Phosphoprotein Phosphatase [NCIt concept]
- Platelet-Activating Factor Acetylhydrolase [NCIt concept]
- Platelet-Activating Factor Acetylhydrolase IB Subunit Alpha2 [NCIt concept]
- Poly(A)-Specific Ribonuclease PARN [NCIt concept]
- Polyphosphoinositide Phosphatase [NCIt concept]
- Prostatic Acid Phosphatase [NCIt concept]
- Protein Artemis [NCIt concept]
- Protein Phosphatase 1D [NCIt concept]
- Protein Phosphatase Slingshot Homolog 1 [NCIt concept]
- Protein Phosphatase Slingshot Homolog 2 [NCIt concept]
- Protein Serine/Threonine Phosphatase [NCIt concept]
- Protein Tyrosine Phosphatase [NCIt concept]
- Protein Tyrosine Phosphatase Type IVA 1 [NCIt concept]
- Protein Tyrosine Phosphatase Type IVA 3 [NCIt concept]
- Putative Hydrolase RBBP9 [NCIt concept]
- Putative Tyrosine-Protein Phosphatase TPTE [NCIt concept]
- RNA Polymerase II Subunit A C-Terminal Domain Phosphatase [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Beta [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase C [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Delta [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Epsilon [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Epsilon Isoform 2 [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Eta [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Gamma [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Kappa [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase O [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase R [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase S [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase T [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase-Like N [NCIt concept]
- Restriction Endonuclease [NCIt concept]
- Ribonuclease [NCIt concept]
- Ribonuclease 3 [NCIt concept]
- Ribonuclease P Protein Subunit p40 [NCIt concept]
- SAM Domain and HD Domain-Containing Protein 1 [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase/Endoribonuclease IRE1 [NCIt concept]
- Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit [NCIt concept]
- Serum Paraoxonase/Arylesterase 1 [NCIt concept]
- Serum Paraoxonase/Arylesterase 2 [NCIt concept]
- Sialate O-Acetylesterase [NCIt concept]
- Sphingomyelin Phosphodiesterase [NCIt concept]
- Sphingomyelin Phosphodiesterase 2 [NCIt concept]
- Sphingomyelin Phosphodiesterase 3 [NCIt concept]
- Sphingomyelin Phosphodiesterase 4 [NCIt concept]
- Sphingosine-1-Phosphate Phosphatase 1 [NCIt concept]
- Sphingosine-1-Phosphate Phosphatase 2 [NCIt concept]
- Steryl-Sulfatase [NCIt concept]
- Synaptojanin-1 [NCIt concept]
- Tartrate-Resistant Acid Phosphatase Type 5 [NCIt concept]
- Tartrate-Resistant Acid Phosphatase Type 5b [NCIt concept]
- Three Prime Repair Exonuclease 1 [NCIt concept]
- Transitional Endoplasmic Reticulum ATPase [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 1 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 11 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 12 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 13 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 14 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 2 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 21 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 22 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 6 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 7 [NCIt concept]
- Tyrosyl-DNA Phosphodiesterase 1 [NCIt concept]
- U6 snRNA Phosphodiesterase [NCIt concept]
- Ubiquitin-Associated and SH3 Domain-Containing Protein B [NCIt concept]
- V(D)J Recombination-Activating Protein 1 [NCIt concept]
- Valacyclovir Hydrolase [NCIt concept]
- Zinc Phosphodiesterase ELAC Protein 2 [NCIt concept]
- cAMP-Specific 3',5'-Cyclic Phosphodiesterase 4B [NCIt concept]
- cAMP-Specific 3',5'-Cyclic Phosphodiesterase 4D [NCIt concept]
- cGMP-Dependent 3',5'-Cyclic Phosphodiesterase [NCIt concept]
- cGMP-Inhibited 3',5'-Cyclic Phosphodiesterase A [NCIt concept]
- cGMP-Specific 3',5'-Cyclic Phosphodiesterase [NCIt concept]
- dGTPase [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]

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