" /> Receptor-Type Tyrosine-Protein Phosphatase-Like N - CISMeF





Preferred Label : Receptor-Type Tyrosine-Protein Phosphatase-Like N;

NCIt synonyms : Islet Cell Antigen 2; Insulinoma-Associated Tyrosine-Phosphatase-Like Protein; Protein Tyrosine Phosphatase-Like N; PTPRN; Receptor Type Protein Tyrosine Phosphatase N; Insulinoma-Associated Protein 2; PTP IA-2; Islet Antigen 2; R-PTP-N; Protein Tyrosine Phosphatase Receptor Type-N; ICA 512;

NCIt related terms : ICA512; PTP-IA2; Islet Cell Autoantigen 3; IA-2; ISLET CELL ANTIGEN 512;

NCIt definition : Receptor-Type Tyrosine-Protein Phosphatase-Like N (979 aa, 106 kDa) is encoded by the human PTPRN gene. This protein is involved in neurotransmitter and hormone secretion.;

Alternative definition : CDISC: An antigen encoded by the PTPRN gene and regulates insulin secretion. It can be considered as an autoantigen and is commonly associated with the autoimmune disease type 1 diabetes.;

NCIt note : Receptor-type tyrosine-protein phosphatase-like N is cleaved into three chains ICA512-N-terminal fragment (ICA512-NTF), ICA512-transmembrane fragment (ICA512-TMF) and ICA512-cleaved cytosolic fragment (ICA512-CCF). ICA512-TMF regulates the exocytosis of insulin secretory granules and ICA512-CCF is translocated to the nucleus where it promotes the expression of the insulin gene and secretory granule genes. (UniProt); Receptor-type tyrosine-protein phosphatase-like N is an autoantigen in insulin-dependent diabetes mellitus (IDDM).;

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29/04/2024


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