Type I Diabetes Mellitus Pathway

Preferred Label : Type I Diabetes Mellitus Pathway;

NCIt related terms : Type I diabetes mellitus;

Alternative definition : KEGG: Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4 T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8 T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).;

KEGG ID : hsa04940;

Details

Origin ID

C91529;

UMLS CUI

C2984334;

Automatic exact mappings (from CISMeF team)
- Diabetes mellitus type 1 (disorder) [SNOMED CT concept]
- Insulin dependent diabetes mellitus [LOINC component]
- Juvenile diabetes [MedDRA LLT]
- Type 1 diabetes mellitus [OMIM Phenotype]
- Type I diabetes mellitus [MedDRA LLT]
- Type I diabetes mellitus [HPO term]
- diabetes mellitus, type 1 [MeSH Descriptor]
- type 1 diabetes mellitus [DO Concept]
See also inter- (CISMeF)
- Diabetes mellitus type 1 [ORDO Disease]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 60 kDa Heat Shock Protein, Mitochondrial [NCIt concept]
- Carboxypeptidase E [NCIt concept]
- Glutamate Decarboxylase 1 [NCIt concept]
- Glutamate Decarboxylase 2 [NCIt concept]
- Granzyme B [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain E [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain F [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain G [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Alpha Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DO Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- Interferon Gamma [NCIt concept]
- Interleukin-1 Alpha [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-12 Subunit Alpha [NCIt concept]
- Interleukin-12 Subunit Beta [NCIt concept]
- Interleukin-2 [NCIt concept]
- Lymphotoxin-Alpha [NCIt concept]
- Perforin-1 [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase-Like N [NCIt concept]
- T-Cell-Specific Surface Glycoprotein CD28 [NCIt concept]
- T-Lymphocyte Activation Antigen CD80 [NCIt concept]
- T-Lymphocyte Activation Antigen CD86 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
pathway_has_gene_element
- CD28 wt Allele [NCIt concept]
- CD80 wt Allele [NCIt concept]
- CD86 wt Allele [NCIt concept]
- CPE wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- GAD1 wt Allele [NCIt concept]
- GAD2 wt Allele [NCIt concept]
- GZMB wt Allele [NCIt concept]
- HLA-DMA wt Allele [NCIt concept]
- HLA-DMB wt Allele [NCIt concept]
- HLA-DOB wt Allele [NCIt concept]
- HLA-DQA1 wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- HLA-E wt Allele [NCIt concept]
- HLA-F wt Allele [NCIt concept]
- HLA-G wt Allele [NCIt concept]
- HSPD1 wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- IL12A wt Allele [NCIt concept]
- IL12B wt Allele [NCIt concept]
- IL1A wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL2 wt Allele [NCIt concept]
- LTA wt Allele [NCIt concept]
- PRF1 wt Allele [NCIt concept]
- PTPRN wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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