T-Lymphocyte Activation Antigen CD80

Preferred Label : T-Lymphocyte Activation Antigen CD80;

NCIt synonyms : BB1; CD28 Antigen Ligand 1; CD80; B7-1; B-lymphocyte Activation Antigen B7-1; B71 Antigen; LAB7; CD28LG; B7; CD28LG1; Activation B7-1 Antigen; CTLA-4 Counter-Receptor B7.1; CD80 Antigen;

NCIt definition : T-lymphocyte activation antigen CD80 (288 aa, 33 kDa) is encoded by the human CD80 gene. This protein is involved in the regulation of T-cell activation.;

NCIt note : A member of the immunoglobulin gene super family. Co-regulator of T cell activation with CD86. Plays a critical role in autoimmune, humoral, and transplant responses. Expressed on activated T and B cells and on macrophages. The natural ligand for the T-cell antigen CD28 (ANTIGENS, CD28) mediating T- and B-cell adhesion. CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes. The binding of CD80 to CD28 and CTLA-4 provides a co-stimulatory signal to T-cells and leads to greatly upregulated lymphokine production.;

Details

Origin ID

C15173;

UMLS CUI

C4048302;

Currated CISMeF NLP mapping
- B7-1 Antigen [MeSH Descriptor]
- B7-1 Antigen [MeSH concept]
OMIM relation
- Cd80 antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CD80 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- B-Lymphocyte [NCIt concept]
- Macrophage [NCIt concept]
- T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- CTLA-4 Ligand [NCIt concept]
- Viral Receptor [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Immunoglobulin-Like V-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Antigen Dependent B Cell Activation Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
- T-Cell Activation Co-Stimulatory Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- T-Cell Activation [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Galiximab [NCIt concept]

Keyword's position in hierarchy(ies) :

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