Preferred Label : Antigen Dependent B Cell Activation Pathway;
NCIt related terms : Antigen Dependent B Cell Activation;
Alternative definition : BIOCARTA: A key part of the immune system is the production of immunoglobulins (antibodies)
by B cells to bind and inactivate specific foreign antigens. The body produces B cells
with a wide range of antigen specificities in their immunoglobulin B cell receptor,
but each cell only has a single specificity. When the B cell receptor immunoglobulin
binds antigen, that cell is activated to proliferate and create plasma cells secreting
immunoglobulins to bind that specific antigen. B cell activation also creates memory
cells with the same antigen specificity that do not actively secrete immunoglobulin
but provide for rapid future immune responses to the same antigen. B cells are not
activated by antigen on their own, but require interaction with helper CD4 T cells
to become activated and proliferate. The B cell first expresses immunoglobulin on
the cell surface as the B cell receptor. If the B cell receptor immunoglobulin binds
specific antigen, then the cell internalizes the antigen and presents it to T cells
in MHC II, where it is recognized by the T cell receptor. In addition to the interaction
between the T cell receptor and the B cell MHC-antigen, T cell interaction with the
B cell involves additional positive and negative regulatory signals. CD40 interaction
with CD40L and CD28 interaction with CD80 provide positive costimulatory signals that
stimulate B cell activation and proliferation. T cell receptor activation induces
expression of molecules like the CD40 ligand that modulate the B cell-T cell interaction.
The CD40-CD40L interaction induces cytokine production and expression of other genes
and alters the fate of the B cell involved in the interaction. If the interaction
between CD40 and CD40L is prolonged, the B cell can be induced to become a memory
cell rather than a plasma cell. Fas ligand binding to Fas between B and T cells may
negatively modulate B cell activation, inducing apoptosis that limits B cell proliferation
and activation. Cytokines like IL-2, IL-4 and IL-10 also play an important role in
B cell activation. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_asbcellPathway;
Origin ID : C38994;
UMLS CUI : C1516012;
- Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element