T-Cell Surface Glycoprotein CD4

Preferred Label : T-Cell Surface Glycoprotein CD4;

NCIt synonyms : CD4; OKT4 Antigen; T-Cell Surface Antigen T4/Leu-3; CD4 Antigen (P55); CD4 Protein; T-Cell Antigen T4/Leu3; CD4 Antigen;

NCIt definition : T-cell surface glycoprotein CD4 (458 aa, 51 kDa) is encoded by the human CD4 gene. This protein plays a role in antigen recognition and HIV entry.;

Details

Origin ID

C16300;

UMLS CUI

C4048280;

Currated CISMeF NLP mapping
- CD4 (76-94) [MeSH concept]
- CD4 (76-94) [MeSH Supplementary Concept]
- CD4 (81-92) [MeSH concept]
- CD4 (81-92) [MeSH Supplementary Concept]
- CD4 Ag [LOINC component]
- CD4 Antigens [MeSH Descriptor]
- CD4 Antigens [MeSH concept]
OMIM relation
- Cd4 antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CD4 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Granulocyte [NCIt concept]
- Macrophage [NCIt concept]
- Monocyte [NCIt concept]
- Thymocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Immunoglobulin Family Protein [NCIt concept]
- Viral Receptor [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Immunoglobulin-Like V-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Antigen Dependent B Cell Activation Pathway [NCIt concept]
- Antigen Processing and Presentation Pathway [NCIt concept]
- Arf1 Signaling Pathway [NCIt concept]
- Bystander B Cell Activation Pathway [NCIt concept]
- CSK Protein Kinase Activation Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- HIV Induced T Cell Apoptosis Pathway [NCIt concept]
- Hematopoiesis Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- IL12/STAT4 Signaling Pathway [NCIt concept]
- IL17 Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL5 Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- TCR Activation Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Systemic Lupus Erythematosus [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- T-Cell Activation [NCIt concept]
is_target
- Anti-CD4 CAR T-cells [NCIt concept]
- Autologous Anti-CD4 CAR T-cells LB1901 [NCIt concept]
- Zanolimumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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