Preferred Label : CD40 Ligand;
NCIt synonyms : TNFSF5; TRAP; T-BAM; TNF-Related Activation Protein; gp39; T Cell Antigen gp39; Tumor Necrosis Factor Ligand Superfamily Member 5; CD40-L; CD40L; IMD3; CD154 Antigen; CD154; HIGM1; T-B Cell-Activating Molecule; T-Cell Antigen Gp39; CD40 Antigen Ligand; CD40LG;
CISMeF synonym : CD40LG; CD154;
NCIt related terms : CD40-ligand;
NCIt definition : CD40 ligand (261 aa, 29 kDa) is encoded by the human CD40LG gene. This protein is
involved in both binding to CD40 and the modulation of B-cell function.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It binds
to certain immune cells and may suppress cancer growth.;
NCIt note : Cell surface marker TRAP (CD40 ligand) is a member of the TNF family and a type II
membrane glycoprotein on T-cells, but absent from B-cells and monocytes. It is expressed
on both CD4- and CD8-positive T-cells. IL4, an inducer of IgE, up regulates TRAP while
gamma-interferon, an inhibitor of IgE, reduces TRAP expression. CD40 is a glycoprotein
expressed on B-lymphocytes, epithelial cells, and some carcinoma cells. Activation
of CD40 mediates B-cell proliferation, adhesion, and differentiation. TRAP mutation
causes X-linked hyper-IgM syndrome (hypergammaglobulinemia). (from OMIM 308230 and
NCI);
Codes from synonyms : CDR0000046759;
Origin ID : C20528;
UMLS CUI : C3887583;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- False automatic mappings
- OMIM relation
- See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
