CD40 Ligand - CISMeF

Preferred Label : CD40 Ligand;

NCIt synonyms : TNFSF5; TRAP; T-BAM; TNF-Related Activation Protein; gp39; T Cell Antigen gp39; Tumor Necrosis Factor Ligand Superfamily Member 5; CD40-L; CD40L; IMD3; CD154 Antigen; CD154; HIGM1; T-B Cell-Activating Molecule; T-Cell Antigen Gp39; CD40 Antigen Ligand; CD40LG;

CISMeF synonym : CD40LG; CD154;

NCIt related terms : CD40-ligand;

NCIt definition : CD40 ligand (261 aa, 29 kDa) is encoded by the human CD40LG gene. This protein is involved in both binding to CD40 and the modulation of B-cell function.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It binds to certain immune cells and may suppress cancer growth.;

NCIt note : Cell surface marker TRAP (CD40 ligand) is a member of the TNF family and a type II membrane glycoprotein on T-cells, but absent from B-cells and monocytes. It is expressed on both CD4- and CD8-positive T-cells. IL4, an inducer of IgE, up regulates TRAP while gamma-interferon, an inhibitor of IgE, reduces TRAP expression. CD40 is a glycoprotein expressed on B-lymphocytes, epithelial cells, and some carcinoma cells. Activation of CD40 mediates B-cell proliferation, adhesion, and differentiation. TRAP mutation causes X-linked hyper-IgM syndrome (hypergammaglobulinemia). (from OMIM 308230 and NCI);

Codes from synonyms : CDR0000046759;

Details

Origin ID

C20528;

UMLS CUI

C3887583;

CISMeF manual mappings
- X-linked hyper-IgM syndrome [ORDO Disease]
Currated CISMeF NLP mapping
- CD40 ligand [MeSH concept]
- Immunodeficiency with hyper-igm, type 1 [OMIM Phenotype]
- cd40 ligand [MeSH Descriptor]
- trapping [IUPAC Term]
False automatic mappings
- Periodic fever, familial, autosomal dominant [OMIM Phenotype]
OMIM relation
- Cd40 ligand [OMIM gene]
See also inter- (CISMeF)
- Hyper-IgM immunodeficiency syndrome, type 1 [MeSH Descriptor]
- Hyper-IgM syndrome due to CD40 ligand deficiency [ICD-11 More detail]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CD40LG Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_expressed_in_tissue
- CD4-Positive T-Lymphocyte [NCIt concept]
- CD8-Positive T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- T-Lymphocyte [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Antigen Dependent B Cell Activation Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Asthma Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Bystander B Cell Activation Pathway [NCIt concept]
- CD40/CD40L Signaling Pathway [NCIt concept]
- CD40L Signaling Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Calcium Signaling in the CD4+ TCR Pathway [NCIt concept]
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
- Th1/Th2 Differentiation Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- B Cell Proliferation [NCIt concept]
- Cell Death Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]
is_target
- Autologous Ad-CD154-Transduced CLL B Cells [NCIt concept]
- Autologous Bladder Cell Carcinoma RNAs/CD40L RNA Electroporated Autologous Matured Dendritic Cells [NCIt concept]
- Letolizumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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