Preferred Label : Autologous Ad-CD154-Transduced CLL B Cells;
NCIt definition : An autologous tumor cell vaccine containing chronic lymphocytic leukemia (CLL) B cells
transduced with an adenoviral vector carrying chimeric CD154 (ad-CD154) with potential
antineoplastic activity. Administration of autologous ad-CD154 transduced CLL B cells
may result in increases in the numbers of leukemia-specific CD4 T cells and high
serum-levels of IL-12 and IFN-gamma. Due to ligation of CD154 to CD40 on CLL cells,
this agent may induce CLL cells to express the proapoptotic molecule BID and death
receptors CD95 (Fas) and DR5, rendering CLL B cells first resistant and then sensitive
to Fas-mediated apoptosis. In addition, autologous ad-CD154 transduced CLL B cells
may induce MHC class I-dependent cytotoxic T lymphocyte (CTL) responses against autologous
leukemia cells. CD154 is a type II membrane glycoprotein and ligand for CD40; both
molecules are important in cognate co-stimulatory cell-cell interactions.;
Drug name : L-Vax;
NCI Metathesaurus CUI : CL374420;
Origin ID : C68842;
UMLS CUI : C2346881;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
