Asthma Pathway

Preferred Label : Asthma Pathway;

NCIt related terms : Asthma;

Alternative definition : KEGG: Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into Th2 cells, a process that is promoted by interleukin 4 (IL-4). Activated Th2 cells stimulate B cells to produce IgE antibodies in response to IL-4 and IL-13. IgE binds the high affinity IgE receptor at the surface of mast cells, the proliferation and differentiation of which is promoted by IL-9.The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Activated mast cells and Th2 cells also induce the production of IL-5. IL-5 travels to the bone marrow and regulates the differentiation and egress of eosinophils from the bone marrow into the blood. Moreover activated mast cells and Th2 cells in the lung generate the cytokines interleukin IL-4, IL-13 and tumour necrosis factor (TNF)-alpha. These cytokines stimulate the generation of eotaxin by lung epithelial cells, fibroblasts and smooth muscle cells. Eotaxin then stimulates the selective recruitment of eosinophils from the airway microvessels into the lung tissue. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.;

KEGG ID : hsa05310;

Details

Origin ID

C91488;

UMLS CUI

C2984299;

Automatic exact mappings (from CISMeF team)
- ASTHMA [WHO-ART Preferred Term]
- Asthma [HPO term]
- Asthma [DeCS]
- Asthma [ICD-10 category]
- Asthma [LOINC component]
- Asthma [PASCAL descriptor]
- Asthma [MedDRA Preferred Term]
- Asthma [HPMULTI term]
- Asthma [ICD-9 code]
- Asthma (disorder) [SNOMED CT concept]
- asthma [ICPC-2 Rubric]
- asthma [MedlinePlus Topic]
- asthma [MeSH concept]
- asthma [DO Concept]
- asthma [Blood Transfusion thesaurus concept]
- asthma [EMDN type]
See also inter- (CISMeF)
- Asthma [ICD-11 Category]
- asthma [Radlex concept]
- asthma [MeSH Descriptor]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- CD40 Ligand [NCIt concept]
- Eotaxin [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Alpha Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DO Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- High Affinity Immunoglobulin Epsilon Receptor Subunit Beta [NCIt concept]
- Interleukin-10 [NCIt concept]
- Interleukin-13 [NCIt concept]
- Interleukin-3 [NCIt concept]
- Interleukin-4 [NCIt concept]
- Interleukin-5 [NCIt concept]
- Interleukin-9 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
pathway_has_gene_element
- CCL11 wt Allele [NCIt concept]
- CD40 wt Allele [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- HLA-DMA wt Allele [NCIt concept]
- HLA-DMB wt Allele [NCIt concept]
- HLA-DQA1 wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- IL10 wt Allele [NCIt concept]
- IL13 wt Allele [NCIt concept]
- IL3 wt Allele [NCIt concept]
- IL4 wt Allele [NCIt concept]
- IL5 wt Allele [NCIt concept]
- IL9 wt Allele [NCIt concept]
- MS4A2 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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