" /> Interleukin-10 - CISMeF





Preferred Label : Interleukin-10;

NCIt synonyms : Cytokine Synthesis Inhibitory Factor; CSIF; IL10; Interleukin 10; TGIF; T-Cell Growth Inhibitory Factor;

NCIt related terms : IL-10;

NCIt definition : Interleukin-10 (178 aa, 21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression.;

Alternative definition : NCI-GLOSS: One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-10 is made by activated macrophages and by some T lymphocytes. It reduces inflammation by blocking production of cytokines by immune cells. IL-10 also increases antibody production by plasma cells and helps them live longer. IL-10 made in the laboratory is used as a biological response modifier to boost the immune system. It is a type of cytokine.;

NCIt note : Interleukin-10 down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.;

Codes from synonyms : CDR0000682069; CDR0000557293;

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03/05/2025


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