Interleukin-10

Preferred Label : Interleukin-10;

NCIt synonyms : Cytokine Synthesis Inhibitory Factor; CSIF; IL10; Interleukin 10; TGIF; T-Cell Growth Inhibitory Factor;

NCIt related terms : IL-10;

NCIt definition : Interleukin-10 (178 aa, 21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression.;

Alternative definition : NCI-GLOSS: One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-10 is made by activated macrophages and by some T lymphocytes. It reduces inflammation by blocking production of cytokines by immune cells. IL-10 also increases antibody production by plasma cells and helps them live longer. IL-10 made in the laboratory is used as a biological response modifier to boost the immune system. It is a type of cytokine.;

NCIt note : Interleukin-10 down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.;

Codes from synonyms : CDR0000682069; CDR0000557293;

Details

Origin ID

C20512;

UMLS CUI

C1699802;

Currated CISMeF NLP mapping
- Interleukin 10 [LOINC component]
- Interleukin-10 [FMA entity]
- Interleukin-10 [MeSH Descriptor]
- Interleukin-10 [MeSH concept]
- interleukin-10 [SNOMED Notion]
False automatic mappings
- Interleukin-10 (substance) [SNOMED CT concept]
OMIM relation
- Interleukin 10 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- IL10 protein, human [MeSH concept]
- IL10 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- IL10 Gene [NCIt concept]
- Interleukin Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Antigen Dependent B Cell Activation Pathway [NCIt concept]
- Asthma Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Cytokine Network Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Dendritic Cell Pathway [NCIt concept]
- Erythrocyte Differentiation Pathway [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- IL10 Anti-inflammatory Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- B Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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