" /> Graft-Versus-Host Disease Pathway - CISMeF





Preferred Label : Graft-Versus-Host Disease Pathway;

NCIt synonyms : GVHD Pathway;

NCIt related terms : Graft-versus-host disease;

Alternative definition : KEGG: Graft-versus-host disease (GVHD) pathophysiology can be summerized in a three-step process. During step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues and induction of inflammatory cytokines [tumour necrosis factor (TNF-alpha) and interleukin (IL-1)] secretion. Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells.;

KEGG ID : hsa05332;

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30/07/2025


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