Graft-Versus-Host Disease Pathway

Preferred Label : Graft-Versus-Host Disease Pathway;

NCIt synonyms : GVHD Pathway;

NCIt related terms : Graft-versus-host disease;

Alternative definition : KEGG: Graft-versus-host disease (GVHD) pathophysiology can be summerized in a three-step process. During step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues and induction of inflammatory cytokines [tumour necrosis factor (TNF-alpha) and interleukin (IL-1)] secretion. Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells.;

KEGG ID : hsa05332;

Details

Origin ID

C91481;

UMLS CUI

C2984293;

Automatic exact mappings (from CISMeF team)
- GRAFT VERSUS HOST DISEASE [WHO-ART Preferred Term]
- Graft versus host disease [MedDRA Preferred Term]
- Graft versus host disease [ORDO Disease]
- Graft-versus-host disease [ICD-11 Category]
- Graft-versus-host disease [ICD-9 code]
- Graft-versus-host disease (disorder) [SNOMED CT concept]
- graft versus host disease [Radlex concept]
- graft vs host disease [MeSH Descriptor]
- graft-versus-host disease [Blood Transfusion thesaurus concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Granzyme B [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain E [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain F [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain G [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Alpha Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DO Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- Interferon Gamma [NCIt concept]
- Interleukin-1 Alpha [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-10 [NCIt concept]
- Interleukin-2 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Killer Cell Immunoglobulin-Like Receptor 2DL1 [NCIt concept]
- Killer Cell Immunoglobulin-Like Receptor 2DL2 [NCIt concept]
- Killer Cell Immunoglobulin-Like Receptor 2DL3 [NCIt concept]
- Killer Cell Immunoglobulin-Like Receptor 3DL1 [NCIt concept]
- Killer Cell Immunoglobulin-Like Receptor 3DL2 [NCIt concept]
- Killer Cell Immunoglobulin-Like Receptor 3DL3 [NCIt concept]
- NKG2-A/NKG2-B Type II Integral Membrane Protein [NCIt concept]
- Natural Killer Cells Antigen CD94 [NCIt concept]
- Perforin-1 [NCIt concept]
- T-Cell-Specific Surface Glycoprotein CD28 [NCIt concept]
- T-Lymphocyte Activation Antigen CD80 [NCIt concept]
- T-Lymphocyte Activation Antigen CD86 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
pathway_has_gene_element
- CD28 wt Allele [NCIt concept]
- CD80 wt Allele [NCIt concept]
- CD86 wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- GZMB wt Allele [NCIt concept]
- HLA-DMA wt Allele [NCIt concept]
- HLA-DMB wt Allele [NCIt concept]
- HLA-DOB wt Allele [NCIt concept]
- HLA-DQA1 wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- HLA-E wt Allele [NCIt concept]
- HLA-F wt Allele [NCIt concept]
- HLA-G wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- IL10 wt Allele [NCIt concept]
- IL1A wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL2 wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- KIR2DL1 wt Allele [NCIt concept]
- KIR2DL2 wt Allele [NCIt concept]
- KIR2DL3 wt Allele [NCIt concept]
- KIR3DL1 wt Allele [NCIt concept]
- KIR3DL2 wt Allele [NCIt concept]
- KIR3DL3 wt Allele [NCIt concept]
- KLRC1 wt Allele [NCIt concept]
- KLRD1 wt Allele [NCIt concept]
- PRF1 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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