Granzyme B - CISMeF

Preferred Label : Granzyme B;

NCIt synonyms : Cytotoxic Serine Protease B; Lymphocyte Protease; HLP; Cathepsin G-Like 1; CTSGL1; Fragmentin; GZMB; Fragmentin-2; C11; SECT; Human Lymphocyte Protein; Cytotoxic T-Lymphocyte Proteinase 2; T-Cell Serine Protease 1-3E; CTLA-1; EC 3.4.21.79; Granzyme-2; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Granzyme 2;

NCIt definition : Granzyme B (247 aa, 28 kDa) is encoded by the human GZMB gene. This protein plays a role in the mediation of cell-dependent cytotoxicity.;

Details

Origin ID

C104268;

UMLS CUI

C1567160;

Automatic exact mappings (from CISMeF team)
- Granzyme B [LOINC component]
- Granzyme B (substance) [SNOMED CT concept]
- Granzyme b [OMIM gene]
- Hyperkeratosis lenticularis perstans [OMIM Phenotype]
- Polymerase III, rna, subunit k [OMIM gene]
- SKI2 subunit of superkiller complex [ORDO Gene]
- aldo-keto reductase family 1 member C4 [ORDO Gene]
- fragmentin [MeSH concept]
- fragmentin [MeSH Supplementary Concept]
- granzyme B [MeSH concept]
- granzyme B [HGNC gene]
- granzymes [MeSH Descriptor]
OMIM relation
- Granzyme b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- GZMB protein, human [MeSH concept]
- GZMB protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GZMB Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
- Natural Killer Cell [NCIt concept]
gene_product_has_associated_anatomy
- Secretory Granule [NCIt concept]
gene_product_has_biochemical_function
- Granzyme [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Apoptotic DNA Fragmentation Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- Granzyme A Mediated Apoptosis Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell-Mediated Cytotoxicity [NCIt concept]
- Hydrolysis [NCIt concept]
- Positive Regulation of Cytolytic Process [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Fluorine F 18 LY3546117 [NCIt concept]

Keyword's position in hierarchy(ies) :

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