Granzyme - CISMeF

Preferred Label : Granzyme;

NCIt synonyms : Granzymes; EC 3.4.21.-; Granule-Secreted Enzyme;

NCIt definition : A family of serine endopeptidases. Members of this family are stored in the granules of cytotoxic T cells. Upon release of the granules, these enzymes enter infected cells where they can proteolytically stimulate caspase activation and initiate apoptosis.;

Details

Origin ID

C20619;

UMLS CUI

C1333877;

Automatic exact mappings (from CISMeF team)
- Granzyme A (substance) [SNOMED CT concept]
- Granzyme a [OMIM gene]
- granzyme A [HGNC gene]
- granzyme A [MeSH concept]
Biochemical function of gene products
- Granzyme A [NCIt concept]
- Granzyme B [NCIt concept]
- Granzyme M [NCIt concept]
Currated CISMeF NLP mapping
- granzymes [MeSH Descriptor]
- granzymes [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- granzymes [MeSH Descriptor]
- granzymes [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Peptidase Gene [NCIt concept]
gene_product_has_biochemical_function
- Serine Protease [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell-Mediated Immunity [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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