Serine Protease

Preferred Label : Serine Protease;

NCIt synonyms : Serine Peptidase; Serine Proteinase;

NCIt definition : Proteases that have a serine residue in the active center of the enzyme. These enzymes catalyze the hydrolysis of covalent peptidic bonds by serine nucleophilic attack. Serine proteases participate in a wide range of functions in the body, including blood clotting, inflammation, and digestion.;

Details

Origin ID

C17123;

UMLS CUI

C2717971;

Automatic exact mappings (from CISMeF team)
- Serine protease (disposition) [SNOMED CT concept]
- proteinase 3 [HGNC gene]
- serine endopeptidases [MeSH Descriptor]
- type II transmembrane serine protease [COVID-19 Thesaurus concept]
Biochemical function of gene products
- Complement C2 [NCIt concept]
- Granzyme [NCIt concept]
- Human Glandular Kallikrein [NCIt concept]
- Kallikrein [NCIt concept]
- Pancreatic Elastase [NCIt concept]
- Tryptase [NCIt concept]
Currated CISMeF NLP mapping
- (diisopropylphosphoryl)serine proteases [MeSH concept]
- (diisopropylphosphoryl)serine proteases [MeSH Supplementary Concept]
- serine proteases [MeSH Descriptor]
- serine proteases [MeSH concept]
False automatic mappings
- Substance with serine protease mechanism of action (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing serine protease (product) [SNOMED CT concept]
- Substance with serine protease mechanism of action (substance) [SNOMED CT concept]
- serine proteases [MeSH concept]
- serine proteases [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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